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News Physiol Sci 14: 49-54, 1999;
1548-9213/99 $5.00
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News in Physiological Sciences, Vol. 14, No. 2, 49-54, April 1999
© 1999 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Dual Role of Nitric Oxide in Islet ß-Cells

Giatgen A. Spinas

G. A. Spinas is Professor, Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, CH-8091 Zürich, Switzerland.
In pancreatic islets, nitric oxide (NO) produced on exposure to cytokines mediates ß-cell injury leading to diabetes mellitus. On the other hand, L-arginine-derived NO may participate in the signal transduction pathway of physiological insulin secretion. This review focuses on the dual role of NO as a mediator of physiological and pathophysiological processes in pancreatic islets.




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