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Physiology 19: 362-369, 2004; doi:10.1152/physiol.00020.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 6, 362-369, December 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Regulation of Ion Transport by the NHERF Family of PDZ Proteins

Shirish Shenolikar, James W. Voltz, Rochelle Cunningham1 and Edward J. Weinman1,2

Department Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710
1 Department of Medicine, University of Maryland School of Medicine, and
2 Department of Veterans Affairs, Baltimore, Maryland 21201

NHERFs are the best-studied apical PDZ proteins that are highly expressed in epithelial cells. Molecular and cellular studies over the past decade show that NHERFs regulate the targeting or trafficking of ion transporters and other membrane proteins and transduce physiological and pathophysiological signals that regulate ion homeostasis in mammals.




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