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Physiology 19: 377-387, 2004; doi:10.1152/physiol.00013.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 6, 377-387, December 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Recent Insights into the Structure and Mechanism of the Sodium Pump

J.-D. Horisberger

Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland

jean-daniel.horisberger{at}ipharm.unil.ch

The sodium pump (or Na-K-ATPase) is essential to the function of animal cells. Publication of the related calcium pump (SERCA) structure together with several recent results from a variety of approaches allow us to propose a mechanistic model to answer the question: "How does the sodium pump pump?"




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