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Physiology 20: 102-111, 2005; doi:10.1152/physiol.00050.2004
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 2, 102-111, April 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Ion Channels in Mesangial Cells: Function, Malfunction, or Fiction

Rong Ma

Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas

Jennifer L. Pluznick and Steven C. Sansom

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska

ssansom{at}unmc.edu

Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming {alpha}-subunit and an accessory ß1-subunit, operate as Ca2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.




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