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Physiology 20: 140-146, 2005; doi:10.1152/physiol.00044.2004
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 2, 140-146, April 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The Protein Tyrosine Kinase-Dependent Pathway Mediates the Effect of K Intake on Renal K Secretion

Dao-Hong Lin1,2, Hyacinth Sterling1 and Wen-Hui Wang1

1 Department of Pharmacology, New York Medical College, Valhalla, New York, and
2 Department of Pharmacology, Harbin Medical University, Harbin, China

wenhui_wang{at}nymc.edu

Dietary K intake plays an important role in the regulation of K secretion: a decrease stimulates and an increase suppresses kidney expression of protein tyrosine kinase (PTK), which plays a role in regulating Kir1.1 (ROMK), which is responsible for K secretion in the cortical collecting duct (CCD) and K recycling in the thick ascending limb. Tyrosine phosphorylation of ROMK channels increases with low dietary K and decreases with high dietary K. Moreover, stimulation of tyrosine phosphorylation of ROMK1 enhances ROMK1 internalization and reduces the K channel number in the cell surface in the CCD.




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