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Physiology 20: 86-90, 2005; doi:10.1152/physiol.00002.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 2, 86-90, April 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TOPICS

Renal Cell-to-Cell Communication via Extracellular ATP

Peter Komlosi, Attila Fintha and P. Darwin Bell

Departments of Medicine and Physiology, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama

pkomlosi{at}uab.edu

In the kidney, macula densa cells communicate with the mesangial cell-afferent arteriolar smooth muscle cell complex through ATP signaling. This signaling process involves release of ATP across the macula densa basolateral membrane through a maxi anion channel and the interaction of ATP with purinergic P2 receptors.




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