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Physiology 20: 91-95, 2005; doi:10.1152/physiol.00003.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 2, 91-95, April 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TOPICS

New fACEs to the Renin-Angiotensin System

Ingrid Fleming, Karin Kohlstedt and Rudi Busse

Vascular Signaling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany

fleming{at}em.uni-frankfurt.de

Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of several cardiovascular diseases. Recent evidence suggests that some of the beneficial effects of ACE inhibitors can be attributed to the activation of a distinct ACE signaling cascade rather than to the changes in angiotensin II and bradykinin levels. Moreover, at least one other ACE homolog (ACE2) plays a significant role in the regulation of heart and kidney function.




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