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Physiology 20: 194-200, 2005; doi:10.1152/physiol.00009.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 3, 194-200, June 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Physiological Mechanisms of Tumor-Cell Invasion and Migration

David H. Geho, Russell W. Bandle, Timothy Clair and Lance A. Liotta

Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

gehod{at}mail.nih.gov

Recent advances in understanding the complex biology of the microenvironment that underlies tumor invasion and migration have revealed novel and promising therapeutic targets. Pharmacological blockade of intra- and extracellular signaling events that regulate migration and survival of multiple cell types may disrupt the host-tumor conspiracy that allows escape from normal developmental regulation.




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