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Physiology 20: 218-224, 2005; doi:10.1152/physiol.00015.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 4, 218-224, August 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TOPICS

Protein-Protein Interactions in the Tetraspanin Web

Shoshana Levy and Tsipi Shoham

Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, California

levy{at}cmgm.stanford.edu

Tetraspanins are evolutionarily conserved membrane proteins that tend to associate laterally with one another and to cluster dynamically with numerous partner proteins in membrane microdomains. Consequently, members of this family are involved in the coordination of intracellular and intercellular processes, including signal transduction; cell proliferation, adhesion, and migration; cell fusion; and host-parasite interactions.




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