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Physiology 20: 232-238, 2005; doi:10.1152/physiol.00004.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 4, 232-238, August 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Mechanical Signals, IGF-I Gene Splicing, and Muscle Adaptation

Geoffrey Goldspink

Basic Division of Basic Medical Sciences and Department of Surgery, Royal Free and University College Medical School, London, UK

goldspink{at}medsch.ucl.ac.uk

Combining physiological and molecular biology methods made it possible to identify and characterize a local muscle growth/repair factor (MGF). Following resistance exercise, MGF "kick starts" muscle hypertrophy and is important in local tissue repair. Loss of muscle mass in old age and certain diseases is associated with an impaired ability to express MGF.




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