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Physiology 20: 382-389, 2005; doi:10.1152/physiol.00029.2005
1548-9213/05 $8.00
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Physiology, Vol. 20, No. 6, 382-389, December 2005
© 2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

New Insights into Biliverdin Reductase Functions: Linking Heme Metabolism to Cell Signaling

Mahin D. Maines

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York

mahin_maines{at}urmc.rochester.edu

Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways (25, 29, 51); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation (1, 25); and a reductase that catalyzes the conversion of biliverdin to bilirubin (27). These, together with the protein’s primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades.




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