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Physiology 21: 181-188, 2006; doi:10.1152/physiol.00058.2005
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 3, 181-188, June 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Wnt/Frizzled Signaling in the Vasculature: New Angiogenic Factors in Sight

T. Néstor H. Masckauchán and Jan Kitajewski

Department of Pathology, OB/GYN and Institute of Cancer Genetics, Columbia University Medical Center, New York, New York jkk9{at}columbia.edu

Wnt growth factors function via Frizzled receptors to affect cellular proliferation, differentiation, apoptosis, and migration. Wnt/Frizzled signaling is now linked to human hereditary disorders with retinal vascular defects, implicating Wnts as angiogenic factors. Here, we discuss Wnts and a novel Frizzled ligand, Norrin, in physiological and pathological angiogenesis.




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