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Physiology 21: 250-258, 2006; doi:10.1152/physiol.00008.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 4, 250-258, August 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes

Sihem Boudina and E. Dale Abel

Division of Endocrinology, Metabolism, and Diabetes, and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah dale.abel{at}hmbg.utah.edu

Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.




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