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Physiology 21: 269-280, 2006; doi:10.1152/physiol.00004.2006
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 4, 269-280, August 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Modulation of Vascular Smooth Muscle Signaling by Reactive Oxygen Species

Alicia N. Lyle and Kathy K. Griendling

Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia kgriend{at}emory.edu

Modulation of signaling in vascular cells by reactive oxygen species (ROS) affects many aspects of cellular function, including growth, migration, and contraction. NADPH oxidases, important sources of ROS, regulate many growth-specific and migration-related signaling pathways. Identifying the precise intracellular targets of ROS enhances understanding of their role in cardiovascular physiology and pathophysiology.




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