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REVIEW

The mTOR Pathway in the Control of Protein Synthesis

Xuemin Wang and Christopher G. Proud

Department of Biochemistry & Molecular Biology, University of British Columbia, Life Sciences Centre, Vancouver, British Columbia, Canada, cgpr{at}interchange.ubc.ca

Signaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.

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