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REVIEW

Decompensation of Cardiac Hypertrophy: Cellular Mechanisms and Novel Therapeutic Targets

Abhinav Diwan and Gerald W. Dorn, II

Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, Ohio, dorngw{at}ucmail.uc.edu

Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.

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				M. Das Apoptosis as a therapeutic target in heart failure Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1322 - H1323. [Full Text] [PDF]

				G. W. Dorn II The Fuzzy Logic of Physiological Cardiac Hypertrophy Hypertension, May 1, 2007; 49(5): 962 - 970. [Full Text] [PDF]