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REVIEW

The Ins and Outs of Secretion from Pancreatic ß-Cells: Control of Single-Vesicle Exo- and Endocytosis

Patrick E. MacDonald¹ and Patrik Rorsman²

¹ Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada; and
² Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom pmacdonald{at}bcell.org

Exocytosis of insulin-containing secretory vesicles in pancreatic ß-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in ß-cells at the single-vesicle level.