Physiology AJP: Heart and Circulatory Physiology
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Physiology 22: 122-130, 2007; doi:10.1152/physiol.00046.2006 Free Article
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 2, 122-130, April 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Structure and Function of ABC Transporters

Kenneth J. Linton

MRC Clinical Sciences Centre, Imperial College Hammersmith Hospital Campus, London, United Kingdom, kenneth.linton{at}csc.mrc.ac.uk

ATP binding cassette transporters are ubiquitous integral membrane proteins that actively transport ligands across biological membranes, a process critical for most aspects of cell physiology. These proteins are important clinically and economically. Their dysfunction underlies a number of human genetic diseases, and the ability of some to pump cytotoxic molecules from cells confers resistance to antibiotics, herbicides, and chemotherapeutic drugs. Recent structure analyses interpreted in light of a large body of biochemistry has resulted in the ATP-switch model for function in which the paired nucleotide binding domains switch between an ATP-dependent closed conformation and a nucleotide-free, open conformation to drive the translocation of ligand.




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