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Physiology 22: 241-251, 2007; doi:10.1152/physiol.00010.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 4, 241-251, August 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Brain Glucose Sensing, Counterregulation, and Energy Homeostasis

Nell Marty1,2, Michel Dallaporta3 and Bernard Thorens1

1 Department of Physiology and Center for Integrative Genomics, Genopode Building, University of Lausanne, Lausanne, Switzerland;
2 Cellular Stress Group, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom; and
3 Laboratoire de Physiologie Neurovégétative, Université Paul Cézanne, Marseille, France Bernard.Thorens{at}unil.ch

Neuronal circuits in the central nervous system play a critical role in orchestrating the control of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected by several glucose-sensing units that are located at different anatomical sites and converge to the hypothalamus to cooperate with leptin and insulin in controlling the melanocortin pathway.




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