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REVIEW

ER-Mitochondria Communication. How Privileged?

Clara Franzini-Armstrong

Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, armstroc{at}mail.med.upenn.edu

Mitochondria have a low affinity for Ca²⁺, but they take up these ions during normal cell activity because they are in close proximity to the sites of calcium entry into the cell and of internal Ca²⁺ release. This gives mitochondria privileged access to cytoplasmic Ca²⁺ without requiring a direct communication with the endoplasmic reticulum.

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