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Physiology 22: 358-365, 2007; doi:10.1152/physiol.00032.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 6, 358-365, December 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TOPICS

In Vivo Calcium Imaging of Neural Network Function

Werner Göbel and Fritjof Helmchen

Department of Neurophysiology, Brain Research Institute, University of Zurich, Zurich, Switzerland goebel{at}hifo.uzh.ch

Spatiotemporal activity patterns in local neural networks are fundamental to brain function. Network activity can now be measured in vivo using two-photon imaging of cell populations that are labeled with fluorescent calcium indicators. In this review, we discuss basic aspects of in vivo calcium imaging and highlight recent developments that will help to uncover operating principles of neural circuits.






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