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Physiology 23: 131-141, 2008; doi:10.1152/physiol.00007.2008
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 3, 131-141, June 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Selective Labeling of Proteins with Chemical Probes in Living Cells

Michael Z. Lin1 and Lei Wang2

1 Department of Pharmacology, University of California at San Diego, La Jolla; and
2 The Jack H. Skirball Center for Chemical Biology & Proteomics, The Salk Institute for Biological Studies, La Jolla, California lwang{at}salk.edu

Selective labeling of proteins with small molecules introduces novel chemical and physical properties into proteins, enabling the target protein to be investigated or manipulated with various techniques. Different methods for labeling proteins in living cells have been developed by using protein domains, small peptides, or single amino acids. Their application in cells and in vivo has yielded novel insights into diverse biological processes.






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