Physiology AJP: Regulatory, Integrative and Comparative Physiology
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Physiology 23: 286-295, 2008; doi:10.1152/physiol.00020.2008
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 5, 286-295, October 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The Role of FXR in Disorders of Bile Acid Homeostasis

Jyrki J. Eloranta and Gerd A. Kullak-Ublick

Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland jyrki.eloranta{at}usz.ch

As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.






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