HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Obermair, F.-J. Articles by Thallmair, M. PubMed PubMed Citation Articles by Obermair, F.-J. Articles by Thallmair, M.

REVIEW

Endogenous Neural Progenitor Cells as Therapeutic Target After Spinal Cord Injury

Franz-Josef Obermair^*, Aileen Schröter^* and Michaela Thallmair

Brain Research Institute, University of Zurich, and Department of Neuromorphology, ETH Zurich, Zurich, Switzerland thallmair{at}hifo.uzh.ch

Growing knowledge about the role of neural progenitor cells supports the hope that stem cell-based therapeutic approaches aimed at restoring function in the lesioned central nervous system can be established. Possible therapies for promoting recovery after spinal cord injury include stimulating the formation of neurons and glial cells by endogenous progenitor cells. This article reviews the current knowledge about the nature of adult progenitor cells in the intact and injured spinal cord and summarizes possibilities and limitations of cellular replacement strategies based on manipulations of endogenous spinal cord progenitor cells and their environment.

^* F.-J. Obermair and A. Schröter contributed equally to this review.